Accredited Facilities

AVANZA conducts GLP-compliant preclinical studies of all types and degrees of complexity at its modern Gaithersburg, Maryland location.  Our 30,600 square feet laboratory and support facility — which incorporate 30,600 square feet of laboratory and support space, including 35 animal rooms, with recently upgraded caging for all species, are AAALAC-accredited and USDA-registered, with OLAW assurance and both DEA and radiation licenses.  Our updated vivarium for small and large animals includes teratology, neurobehavioral, and surgery areas.  Data are collected online using the Provantis^TM and Ponemah^TM automated data collection systems.

Every effort is made to ensure the ongoing environmental integrity of the facility.  Temperature, humidity, lighting, and watering for animals are all continuously monitored under computer control to comply with all relevant regulatory requirements.  The HVAC system provides HEPA-filtered air and maintains room air changes in accordance with the Guide for the Care and Use of Laboratory Animals.  In addition, the facility is equipped with back-up emergency generators to supply electrical power in the event of a power outage.

Facility access is limited to personnel only.  AVANZA employs key cards, security cameras, and background checks.

 

Preclinical Services Portfolio

AVANZA helps clients plan and conduct safety assessment studies to assist compound development programs involving small molecules, biologics, nutraceuticals, vaccines, chemicals, and intermediates.  We conduct in vivo studies in duration from acute to chronic. 

• General toxicology

• Vaccine safety

• Developmental and Reproductive Toxicology (DART)

• Safety pharmacology

• Vaccine safety

• Pathology services through our partnership with Vet Path Services, Inc. (VPS)

• Analytical chemistry

Species

• Mouse

• Rat

• Rabbit

• Guinea pig

• Canine

• Minipig

• Non-human primates

• Pig / Swine

Routes of Administration

• Continuous infusion

• Dermal

• Ocular

• Oral (gavage, capsule, diet, drinking water, etc.)

• Parenteral (I.V., I.M., S.C., I.P., I.A., etc.)

• Vaginal and rectal

• Customized

Superior Services, Proven in Hundreds of Studies

The AVANZA team has successfully conducted over 1600 preclinical studies at its state-of-the-art, modern facilities.  These have included both short- and long-term research efforts, ranging in duration from less than 1 week to 52 weeks or longer, that have utilized our full range of preclinical research services:

• General Toxicology — focusing on carcinogenicity and acute, subchronic, and chronic toxicity

• Vaccine Safety — experienced with a broad range of agents

• Safety Pharmacology — testing cardiovascular, renal/urinary, gastrointestinal, central nervous systems, and respiratory

• Reproductive Toxicology (DART) — ranging from fertility and embryo-fetal development to neurotoxicity and neonatal dosing studies

• Product Development Services

Fully Accredited Facility

• Use of Provantis^TM and Ponemah^TM data acquisition software

• Program management

• Board-certified toxicologists and board-certified pathologists through our partnership with VPS, Inc.

• GLP-compliant,  AAALAC-accredited, USDA-registered, OLAW assurance, DEA, and radiation licenses.

• Animal welfare procedures

• Strict confidentiality and data security

• Rigorous staff technical training and certification program

All studies are supported by onsite clinical pathology evaluation tools and technology — for hematology, clinical chemistry, coagulation, and urinalysis.  These onsite capabilities facilitate ongoing research, speed data analysis, and help ensure timely project completion.