Overview

Developmental and Reproductive Toxicology (DART) studies are an important specialization of AVANZA’s comprehensive toxicology offering.  Our technical staff evaluates all stages of reproduction and development, enabling us to gather the most appropriate and focused animal data for estimating the stages of greatest potential human reproductive risk.  Each study is designed to meet the scientific and regulatory standards.

 

The Scope of Our Services

The AVANZA team has more than a decade of combined experience conducting DART studies in small animals performed at our AAALAC accredited facility. This rich history and experience means that we can offer a complete range of GLP-compliant study services that meet global regulatory test guidelines across a wide array of studies, including:

• Fertility (male and/or female) - Segment I

• Embryo-fetal development - Segment II

• Prenatal and postnatal development, including maternal function - Segment III

• Multigenerational studies

• Neurotoxicity studies

• Neonatal dosing studies
  

At AVANZA, we are experienced and skilled in undertaking DART studies that utilize both routine and specialized routes of administration that include:

• Continuous infusion

• Dermal

• Dietary

• Intramuscular

• Intravenous

• Oral (gavage, water, capsule)

• Rectal

• Vaginal

A Full Range of Specialized Services

AVANZA can perform fetal evaluations in rats, rabbits, mice, and guinea pigs. In addition, we offer specialized services to meet your needs, including biologicals/vaccines, spermatogenesis evaluations of cellular endpoints (morphology, motility, spermatid head count) via the Hamilton-Thorne IVOS Cell Analysis System, vaginal cytology evaluations for both the pharmaceutical industry and the National Toxicology Program (NTP).

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